Brighton's 3-0 victory at the Emirates all but dashed Arsenal's fading title dream last season, and another loss to the Seagulls would be detrimental for Mikel Arteta's side ahead of a daunting trip to Anfield.
The festive period is upon us with the Gunners needing to return to winning ways on Sunday. They were beaten 1-0 by Aston Villa last time out in the Premier League which saw them relinquish their spot at the summit.
Arsenal should be emboldened by Brighton's Thursday night exploits which could leave them worse for wear, and Arteta will once again shuffle his pack following Tuesday's draw in Eindhoven.
Here's how the Gunners could lin up against the Seagulls this weekend.
Predicted Arsenal lineup vs Brighton
GK: David Raya - Raya earned a breather in midweek as Aaron Ramsdale finally got a Champions League start, but the Spaniard remains Arsenal's number one.
RB: Ben White - The English defender could match-up against Kaoru Mitoma on Sunday - a duel that will prove key in determining the game's victor.
CB: William Saliba - The Frenchman missed the 3-0 defeat to the Seagulls last season because of a back injury.
CB: Gabriel - The Brazilian was forced to play the full 90 in Eindhoven and he produced one of his clumsiest displays of the campaign. Gabriel will be looking to produce a much cleaner performance this weekend.
LB: Oleksandr Zinchenko - Zinchenko will be well-rested for this one and is a sure bet to return to the lineup. We've seen the Ukrainian's playmaking instincts from deep come to the fore in recent weeks.
DM: Declan Rice - The £105m superstar may be a defensive option for Arteta, but he'll be stationed in his natural habitat against Brighton.
CM: Martin Odegaard - The Seagulls' man-to-man press will test Arsenal in possession, and the hosts need the skipper to stand up in the face of pressure and distribute to the attackers in space.
CM: Kai Havertz - The German has enjoyed a nice run in the team and is undoubtedly starting to look settled in north London. He'll continue as Gabriel Jesus' auxiliary strike partner on Sunday.
RW: Bukayo Saka - De Zerbi will allow Saka to attack Brighton's left-back one-v-one, and the Arsenal star could be in for a productive day if his teammates can get him the ball.
ST: Gabriel Jesus - Jesus' movement will be crucial in pulling apart the Seagulls' backline and giving the wingers (and Havertz) space to exploit in behind.
LW: Gabriel Martinelli - Like Saka, Martinelli should get plenty of one-v-one opportunities on Sunday. Can the Brazilian rediscover his most potent form?